The Karam Lab is focused on the tumor immune and vascular microenvironment and how it influences cancer cell growth—especially resistance to therapy. Ongoing projects include:
- Regulatory T cell (Treg) signaling, trafficking, and reprogramming
- Mechanisms of NK cell-dendritic interaction and inactivation by RT
- Induction and effect of systemic immunity and memory
- Mechanisms of neuroimmunology of cancer and elucidating the immunological effects of surgical treatment
- Modulation of endothelial cell trafficking of immune cells and antigen presentation by RT
- Effect of RT-induced fibrosis on tumor immune response and metastasis
- Mechanisms of tumor angiogenesis, lymphangiogenesis, and cancer cell death by Eph-ephrin signaling